8 Popular Skincare Ingredients in 2025 According to Dermatologists

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CANTIKA.COM, Jakarta - Skincare products continue to evolve. Every year, there are always new ingredients that become a topic of conversation. In 2025, the trending skincare ingredients are far more advanced and unique than ever before. There are microorganisms, ingredients derived from yeast, and even plant-based adaptogens promising improved skin health and radiance in an instant.

However, with so many skincare ingredients being hyped, differentiating between virality and genuine science-based innovation can be difficult. Therefore, let's together explore the popular skincare ingredients in 2025 according to dermatologists. Their functions and benefits are also dissected.

1. Exosome

Currently, you may have heard the term exosome. Simply put, according to dermatologist Dendy Engelman, exosome is a messenger particle that carries proteins and genetic material to other cells.

"In skincare, exosome is being explored because of its potential to support the skin's repair process and improve overall skin health," she said as quoted by Byrdie.

"The exosome used by doctors in clinical settings is usually more concentrated than those found in skincare products, and is often administered through procedures such as microneedling or injections, allowing it to penetrate deeper and work more intensively." She noted that dermatologists use exosome to expedite the healing process after specific procedures in the clinic.

On the other hand, topical exosome is formulated to be on the skin surface and gradually support the natural repair process. Engelman stated, "Exosome carries key messengers that prompt cells to repair and regenerate, which can result in smoother texture, better elasticity, and a more radiant appearance."

Supporters of exosome believe that it also has a place in hair care routines. Engelman explained that exosome can aid in hair growth by sending signals to hair follicles to prolong the hair growth phase, resulting in thicker and healthier hair over time.

However, it should be noted that, to date, exosome has not been approved by the U.S. Food and Drug Administration (FDA), sparking controversy. "Although research is still ongoing, exosome is an intriguing innovation that can complement existing approaches to maintain skin health and elasticity," said Engelman.

2. PDRN

If you often see PDRN (polydeoxyribonucleotide) creams and serums on social media, it's because the ingredient continues to receive a lot of attention due to its regenerative properties. But what exactly is PDRN? Dermatologist David Kim describes it as a fragment of salmon sperm DNA.

"This ingredient is widely used in Korea as an injectable and skincare ingredient because PDRN can improve skin elasticity, firmness, texture, and we can also use it on sensitive skin," he said.

PDRN is also a good choice for post-procedure recovery, such as after laser or microneedling. Although skincare products based on PDRN are currently popular, Kim stated that PDRN in injection form represents a completely new category. "Rejuran is the first injection product of PDRN, but this new type of injection product does not shape or contour the face, but rejuvenates and hydrates the skin without altering your appearance," he added.

3. Miniprotein

2025 is the year of miniprotein. Though similar to peptides, what sets miniproteins apart is their formulation and way of function. Dermatologist Marisa Garshick described miniproteins as short chains of amino acids that function as signaling molecules.

"Miniproteins instruct the skin to perform specific functions such as collagen production, hydration, or healing," she said.

Because miniproteins are slightly longer, Garshick stated that they can fold into a clearer three-dimensional shape, allowing for higher specificity and more targeted results when binding to specific receptors.

Another benefit of miniproteins is when combined with active ingredients that stimulate collagen within the skin (such as vitamin C, retinol, peptides, and growth factors), they help enhance the benefits for more dramatic improvement.

4. Plant-Based Adaptogens

For years, adaptogens such as ashwagandha, holy basil, ginseng, reishi, and rhodiola have firmly held their position in the world of supplements. Now, these famous stress relievers are starting to make a name in skincare. "These ingredients have been used in traditional medicine for centuries because of their ability to help the body adapt to stress, and are now applied to the skin to combat oxidative stress, reduce inflammation, and support the skin's natural barrier," said Garshick.

Throughout the remainder of 2025 and into 2026, it is expected to see more plant-based adaptogens emerging as primary ingredients in every skincare category. "We will see plant-based adaptogens in everything, from cleansers and serums to moisturizers, oils, masks, and much more," stated Engelman.

5. NAD

NAD (nicotinamide adenine dinucleotide) is a natural element found in the body. However, like other essential components for healthy skin, such as peptides and collagen, the natural production and quality of NAD decrease with age. With the reduced circulation of NAD in the body, signs of aging become more apparent.

NAD is one of the skincare ingredients for repairing damaged DNA, focusing on rebuilding the skin at a cellular level. Although Engelman stated that NAD is still a relatively new topical skincare ingredient, its usage is becoming more common, and there is some valid scientific evidence.

"Studies have shown that NAD can aid in cell repair, reduce signs of aging, and improve the skin's protective function," she said.

"Currently, there is an interest in functional treatment ingredients in skincare because people are seeking a more holistic approach focused on addressing the root causes to maintain skin health, rather than instant solutions. It's about treating the skin as an extension of overall health."

6. Ectoin

Ectoin has quickly become a must-have soothing, cooling, and stress-reducing skincare ingredient. According to Garshick, ectoin (sometimes classified as extremolyte) provides protection from external stressors and helps moisturize the skin while strengthening its protective barrier.

"Ectoin creates a protective layer on the skin that helps reinforce the skin's protective barrier and prevent moisture loss," she said. "By protecting against external stressors, ectoin also provides protection against blue light and pollution."

This antioxidant-rich ingredient comes from microorganisms and helps them survive in some of the harshest geographical conditions. "In skincare, ectoin helps stabilize cell membranes and maintain hydration, which is key to keeping the protective skin barrier strong and resilient," explained Engelman. "Ectoin is a very good ingredient for dry or problematic skin because it helps the skin retain moisture and maintain its natural balance."

7. Malassezin

Malassezin has quickly gained a reputation as the next-generation vitamin C, offering better stability and gentleness in reducing hyperpigmentation, sun spots, dark spots, and various types of skin discoloration. "Like vitamin C, malassezin helps brighten and even out skin tone, and protect from environmental stressors," said Engelman. "It is also a great alternative, especially for sensitive skin types or those battling redness or inflammation."

This multifunctional ingredient helps reduce discoloration and fade hyperpigmentation by inhibiting the overproduction of melanin. Engelman stated that this process helps diminish existing dark spots and prevent the formation of new ones.

"Malassezin also has strong antioxidant properties, which helps reduce oxidative stress, the main cause of hyperpigmentation," she explained. "It can be very beneficial for those with melasma or acne scars."

8. Spicules

Spicules, which first gained popularity in Korean skincare products, are essentially small needle-like structures derived from sea sponges that help exfoliate the skin and create microchannels to open pores. The purpose of using spicules in skincare is to achieve results similar to microneedling, allowing skincare ingredients applied to penetrate the skin more deeply and absorb more effectively.

Kim stated that spicules can also help improve skin texture and reduce hyperpigmentation, and some research suggests that its exfoliating effect can help address acne. "Spicules do not replace microneedling treatments in clinics, but can help maintain their results for as long as possible," he said.

Those are some of the skincare ingredients that have gained attention until mid-2025 according to dermatologists. Which one are you most familiar with?

BYRDIE

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